zyban banned in europe

Zyban was licensed for use as an anti-smoking drug in June 2000. The list of product names concerned is given in the Annex I. With time, however, this effect becomes negligible. Discovery CEO David Zaslav says CNN is 'making real progress' by adding GOP guests in its effort to lure back viewers, 'Prayer works': Hero ex-marine FINDS missing two-year-old boy in woods 24 hours after he wandered away from his Florida home while his mom was sleeping - as sheriff chokes back tears, Mega-prison in El Salvador for 40,000 suspected gangsters - which has only 80 beds for every 100 inmates - welcomes its first new inmates with vow 'You will never walk out of here', 'How many times does he have to say it for you to believe it?' It is strongly dose-dependent: for the immediate release preparation, the seizure incidence is 0.4% at the dose 300450mg per day; the incidence climbs almost ten-fold for the higher than recommended dose of 600mg.[20] For comparison, the incidence of unprovoked seizure in the general population is 0.07 to 0.09%, and the risk of seizure for a variety of other antidepressants is generally between 0 and 0.5% at the recommended doses. WebThe European Unions executive branch has temporarily banned TikTok from employee phones, and Denmark and Canada have announced efforts to block TikTok on [140][141][142][143], In Russia bupropion is banned as a narcotic drug, yet not per se but rather as a derivative of methcathinone. 5. [68] Likewise, a 2022 systematic review and meta-analysis of bupropion for sexual desire disorder in women reported that although data were limited, bupropion appeared to be dose-dependently effective for the condition. This is also true in Saudi Arabia. Anyone who breaks the law risks a fine or up to seven days in jail. [26][27][28] For comparison, the NDRI methylphenidate at therapeutic doses is thought to occupy greater than 50% of DAT sites. [125], In October 2007, two providers of consumer information on nutritional products and supplements, ConsumerLab.com and The People's Pharmacy, released the results of comparative tests of different brands of bupropion. Dr Julian Spinks is a Kent GP and a member of Smoking Cessation Action in Primary Care, SCAPE. [46], Bupropion has several features that distinguish it from other antidepressants: for instance, unlike the majority of antidepressants, it does not usually cause sexual dysfunction, and the occurrence of sexual side effects is not different from placebo. In 1997, bupropion was approved by the FDA for use as a smoking cessation aid under the name Zyban. Part of the Daily Mail, The Mail on Sunday & Metro Media Group, 'He is NOT a threat': Mental health advocate DEFENDS 6'6" thug, 17, who had to be dragged off unconscious female teaching aide who he knocked out for confiscating his Nintendo Switch, 'Are you a family annihilator, Mr Murdaugh?' [11], Bupropion is metabolized in the body by a variety of pathways. Since licensing, concerns were raised in relation to the reports of suspected adverse drug reactions (ADRs) received associated with the use of bupropion containing medicinal products, particularly those of seizure and fatalities. WebZYBAN has not been studied in children under the age of 18 and is not approved for use in children and teenagers. Deals and discounts in Pet Parents you dont want to miss. Save up to 50% on Games & Activities when you shop now. T.J. Holmes and Amy Robach are so much in love they can't keep their hands off each other on their Mexican idyll as her marriage to Andrew Shue comes close to its end, How Roald Dahl's family caved in to censors to keep their whizzpopping $444million gravy train on track, writes ALISON BOSHOFF, 'Trad housewife' reveals she loves being 'subservient' to her husband, I lived for years in a sexually liberated lesbian commune, but only found true peace and equality when I married a man and became a devoted mother from a leading feminist author comes a book guaranteed to enrage the sisterhood, 'Roald Dahl was a bigot and he never supported me, but really?' The good news here is that bupropion/Zyban has, in most cases, no discontinuation symptoms from stopping cold turkey. Farm animal drugs The animal drug ractopamine, which is administered to animals on U.S. farms to fatten cattle, turkeys, and pigs before slaughter, is banned in Europe along with bovine growth hormone, which the U.S. dairy industry uses to increase milk production in animals. Millions of people are taking the drug and one-third of them are kicking the nicotine habit for good. Ten single-use plastic (SUP) products that for years have blighted Europe's beaches will be largely banned from July 3 as the EU's Single-Use Plastics Directive of 2019 comes into force. But they come at a time when Western technology [98][99] Interactions with other CYP2D6 substrates, such as metoprolol, imipramine, nortriptyline,[99] venlafaxine,[94] and nebivolol[11] have also been reported. [137], While bupropion demonstrates some potential for misuse, this potential is less than of other commonly used stimulants, being limited by features of its pharmacology. On it 10 weeks now. [15] However, there were methodological limitations with this meta-analysis, including using a subset of only five trials for the effect size calculation, substantial variability in effect sizes between the selected trialswhich led the authors to state that their findings in this area should be interpreted with "extreme caution"and general lack of inclusion of unpublished trials in the meta-analysis. Save up to 50% on Dining & Entertaining when you shop now. [132] This advisory was based on a review of anti-smoking products that identified 75 reports of "suicidal adverse events" for bupropion over ten years. [134], In 2012, the U.S. Justice Department announced that GlaxoSmithKline had agreed to plead guilty and pay a $3 billion fine, in part for promoting the unapproved use of Wellbutrin for weight loss and sexual dysfunction. [78] The available forms of bupropion hydrochloride include IR (instant-release) tablets (50, 75, 100mg), SR (sustained-release) tablets (50, 100, 150, 200mg), and XL (extended-release) tablets (150, 300, 450mg). Usage. Shop the best selection of deals on Cat Supplies now. WebParis/London CNN . Is your pharmacy trying to get some for you? Of those, it says 63 reports had "a fatal outcome". [11] Bupropion has no meaningful direct activity at a variety of receptors, including - and -adrenergic, dopamine, serotonin, histamine, and muscarinic acetylcholine receptors. [101], The mechanism of action of bupropion in the treatment of depression and for other indications is unclear. Some cases may have been complicated by the symptoms of nicotine [96] Bupropion has also been found to increase levels of atomoxetine by 5.1-fold, while decreasing the exposure to its main metabolite by 1.5-fold. [45] Bupropion also improves depression in bipolar disorder, with the efficacy and risk of affective switch being similar to other antidepressants. This week, a coroner in Cheshire said that there may have been a link between the suicide of a teenager, Nick Hirst, and his decision to take Zyban to stop smoking. Shop our favorite Bath & Body finds at great prices. (Presentation at Psychopharmacologic Drugs Advisory Committee; December 13, 2006)", "Antidepressant Withdrawal and Rebound Phenomena", "Suicidal antidepressant overdoses: a comparative analysis by antidepressant type", "Highlight os Prescribing Information: CONTRAVE (naltrexone hydrochloride and bupropion hydrochloride) extended-release tablets, for oral use", "Evaluation of a Potential Metabolism-Mediated Drug-Drug Interaction Between Atomoxetine and Bupropion in Healthy Volunteers", "Bioequivalence and Therapeutic Equivalence of Generic and Brand Bupropion in Adults With Major Depression: A Randomized Clinical Trial", "Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation", "Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET study", "Amphetamine positive toxicology screen secondary to bupropion", 10.1002/1520-6394(2000)12:1<53::AID-DA8>3.0.CO;2-4, "Frequency of false positive amphetamine screens due to bupropion using the Syva EMIT II immunoassay", "15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL", "Bupropion helps people with schizophrenia quit smoking", "Drug Approval Package: Wellbutrin XL (Bupropion HCI) NDA #021515", "Drug Approval Package: Zyban NDA# 020711", "Seasonal affective disorder drug Wellbutrin XL wins approval", "Zyban: sevrage tabagique et scurit d'emploi", "Report questions generic antidepressant", "Review of therapeutic equivalence: generic bupropion XL 300mg and Wellbutrin XL 300mg", "Budeprion XL 300mg not therapeutically equivalent to Wellbutrin XL 300mg", "FDA Approvals: Advair, Relistor, Aplenzin", "Drug Approval Package: Aplenzin (Bupropion Hydrobromide) NDA 22108", "Public Health Advisory: FDA requires new boxed warnings for the smoking cessation drugs Chantix and Zyban", "The smoking cessation aids varenicline (marketed as Chantix) and bupropion (marketed as Zyban and generics) suicidal ideation and behavior", "Safety Alerts for Human Medical Products - Chantix (varenicline) and Zyban (bupropion)", "Glaxo agrees to pay $3 billion in fraud settlement", "EMA recommends suspension of medicines due to unreliable studies from Micro Therapeutic Research Labs", "Products for which the marketing authorisations are recommended for suspension and marketing authorisation applications which do not satisfy the criteria for authorisation as adopted by the CHMP", Antidepressant Wellbutrin becomes 'poor man's cocaine' on Toronto streets, " 30 1998 . N 681 " , , " ( )", Drugs for erectile dysfunction and premature ejaculation, Trimetaphan camsilate (trimethaphan camsylate), Muscarinic acetylcholine receptor modulators, Acetylcholine metabolism/transport modulators, Serotonin antagonists and reuptake inhibitors, GlaxoSmithKline Services Unlimited v Commission, https://en.wikipedia.org/w/index.php?title=Bupropion&oldid=1141276433, Attention deficit hyperactivity disorder management, Norepinephrinedopamine reuptake inhibitors, World Health Organization essential medicines, Wikipedia articles needing page number citations from December 2015, Wikipedia indefinitely move-protected pages, Articles containing potentially dated statements from October 2013, All articles containing potentially dated statements, Wikipedia medicine articles ready to translate, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 24 February 2023, at 06:52. The Pharma Letter39 to 43 Putney High StreetPutneyLondonSW15 1SP, For trial and subscription enquiries please email [emailprotected], For editorial enquiries, press releases and events please email[emailprotected], For all other queries please email [emailprotected], If you are already a registered user please, The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. Side effects include agitation, change in appetite, constipation, diarrhoea, dizziness, dry mouth, headache, increased perspiration, insomnia, nausea or vomiting. Theyve collected over 1.5 million signatures, well above the 1 million signatures mark that forces the European Commission to take a serious look at a citizens initiative, Trouw reports. Shop our favorite Decor finds at great prices. The European Parliament on Tuesday banned TikTok from staff devices over cybersecurity concerns, meaning the Chinese video-sharing app is now [139] However, bupropion, by non-conventional routes of administration like injection or insufflation has been reported to be misused in the United States and Canada, notably in prisons. [26][28][27] More research is needed in this area. I'm on 300mg zyban (in Ireland too) but going to drop down to 150mg due to tiredness, brain fog and neck pain. Find the best deals on Outdoor Shades & Structures from your favorite brands. WebA ban on communist symbols was first proposed in 2010, but it failed to define the applicable sanctions. The referral procedure started on 22 February 2002. More rarely, the drug can cause blurred vision, hair colour changes, nightmares, sexual problems, ringing in the ears and suicidal thoughts. For the United Kingdom, as of 1 January 2021, European Union law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland / NI. Carrie Madormo is a business and wellness writer for internationally-recognized publications. If your destination country has an absolute ban on your medication and your health requires that you continue your medication without interruption, Dr. Zegans says, youll have to change your plans., If youre thinking, Who would know if I packed this? think again. Most of the experts disagree with Lorraine. The oxidative pathways are by cytochrome P450 isoenzymes CYP2B6 leading to R,R- and S,S-hydroxybupropion and, to a lesser degree, CYP2C19 leading to 4'-hydroxybupropion. I realise it's important to give up smoking but use something else. And dont miss these 9 immunizations and medications you need to know about before you travel. These are the best Small Pets Supplies deals youll find online. [79][80], The drug label advises that bupropion should not be prescribed to individuals with epilepsy or other conditions that lower the seizure threshold, such as anorexia nervosa, bulimia nervosa, benzodiazepine or alcohol withdrawal. These controlled drugs require a prescription and could put you in hot water outside the United States. Combining bupropion and nicotine replacement therapy does not improve the quitting rate. Manufactured by the British pharmaceutical company GlaxoSmithKline, it works by acting on the [96], Bupropion and its metabolites are inhibitors of CYP2D6, with hydroxybupropion responsible for most of the inhibition. [24] For significant overdoses, seizures have been reported in about a third of all cases; other serious effects include hallucinations, loss of consciousness, and abnormal heart rhythms. The tests showed that "one of a few generic versions of Wellbutrin XL 300mg, sold as Budeprion XL 300mg, didn't perform the same as the brand-name pill in the lab. [11] Overall action of these metabolites, and particularly one enantiomer S,S-hydroxybupropion, is also characterized by inhibition of norepinephrine and dopamine reuptake and nicotinic antagonism (see the chart on the right). [7][23], Although studies are lacking, a handful of case reports suggest that abrupt discontinuation of bupropion may cause antidepressant discontinuation syndrome. Lorraine Vallery knew there was something badly wrong when she began locking herself in the bathroom as a defence against killing her own children. It is used in patients 14 and older; patients also must weigh at least 89 lbs. Zyban is no longer available in brand name; it was originally made by GlaxoSmithKline. Germany and Italy are threatening to block a European Union plan that would effectively ban new combustion-engine vehicles after 2035 unless the blocs executive [29][30], After oral administration, bupropion is rapidly and completely absorbed reaching the peak blood plasma concentration after 1.5 hours (tmax). [138] Case reports describe misuse of bupropion as producing a "high" similar to cocaine or amphetamine usage but with less intensity. [19], Common adverse effects of bupropion with the greatest difference from placebo are dry mouth, nausea, constipation, insomnia, anxiety, tremor, and excessive sweating. And I was terrified that if I started I might kill them.". Belgium has banned full-face veils in public since July 2011. If discovered, your medication will be confiscated at a minimum, placing your health at risk. Bupropion, sold under the brand names Wellbutrin and Zyban among others, is an atypical antidepressant primarily used to treat major depressive disorder and to support smoking cessation. Prescribers are warned that people under 18, An EWG study of laboratory tests of 51 sunscreen products found that only 35 percent of the products tested met the EU standard, but 94 percent would pass the current U.S. standard. healthcare professionals, patient organisations, individual patients) (if applicable), Stakeholder submission form form to be used by stakeholders to submit data (if applicable), Scientific conclusions scientific conclusions of the PRAC and/or CHMP and/or CMDh, Assessment report PRAC or CHMP assessment and conclusions on the issues investigated, including divergent positions (if applicable), Divergent positions divergent positions of the CHMP or CMDh members for pharmacovigilance procedures (if applicable), Changes to the summary of product characteristics, labelling and package leaflet (amended sections or fully revised version) (if applicable), Condition(s) to the marketing authorisation(s) condition(s) for the safe and effective use of the medicine(s) (if applicable), Condition for lifting the suspension condition to be fulfilled for the suspension of the marketing authorisation(s) to be lifted (if applicable), Timetable for implementation of CMDh position agreed timeframe to submit and finalise the variation(s) implementing the outcome of the procedure (if applicable). Web24 July 2019. Yes, a few. "It was a living nightmare, except it didn't feel much like living," she recalls. He says: "The patients I have prescribed with Zyban have had extremely positive results with it. It is also possible that the package could be confiscated at the border. Now that you know how to handle your meds, feel free to ignore these 10 popular travel tips that are no longer true. [89], Bupropion prescribed for smoking cessation results in 25% increase of the risk of psychiatric side effects, in particular, anxiety (about 40% increase) and insomnia (about 80% increase). Already, Alexander Harris, the Cheshire firm of solicitors that dealt with Nick's case, has been approached by more than 40 people complaining of serious side effects after taking Zyban. Did you notice much difference between apotex instant release v zyban prolonged release? Her writing has been featured in Working Mother, USA Today, and the Huffington Post. Im afraid hell recommend Effexor and Ive had horrible side effects from that before (mainly tinnitus that I still have 6 years later), I wont touch that stuff again. "My children are good kids but I wanted to scream and shout at them. Outrage as GP claims healthcare professionals are 'financially invested in killing people'. Had to visit a couple pharmacies to find one with stock, and most couldn't order it. Germany requested the CPMP to give an opinion on whether the marketing authorisations of bupropion containing products indicated as aid to smoking cessation in combination with motivational support in nicotine-dependent patients should be maintained or changed in the terms of marketing authorisation or withdrawn, based on the reported serious suspected adverse reactions associated with these products, in particular reports on depression, suicidal ideation, suicide, seizures, undesirable cardiovascular effects, and angioedema, which raise potential public health concerns. Fur coats made from foxes or minks Find the best deals on Home Gym from your favorite brands. I thought I might kill them or myself. [14][15] It is also popular as an add-on medication in the cases of "incomplete response" to the first-line selective serotonin reuptake inhibitor (SSRI) antidepressant. [26][27][108] These findings raise questions about the role of dopamine reuptake inhibition in the pharmacology of bupropion, and suggest that other actions may be responsible for its therapeutic effects. For the time being, it would appear that the numbers are stacked on the side of Zyban. The growing body of evidence of neonics harmful effects finally led to a more comprehensive ban in Europe in 2018. GlaxoSmithKline refuses to say how much money it is making from Zyban, but it is thought to run into tens of millions of pounds. Most have found it the best way to stop smoking and none has had any serious adverse reactions. I know its available in the Netherlands, not sure about elsewhere in Europe. Is given in the Netherlands, not sure about elsewhere in Europe in.. Comprehensive ban in Europe internationally-recognized publications to define the applicable sanctions sure about elsewhere in Europe for use as defence. V zyban prolonged release none has had any serious adverse reactions in Working Mother USA! Patients also must weigh at least 89 lbs have prescribed with zyban have had positive. This area the efficacy and risk of affective switch being similar to other antidepressants deals and discounts Pet. A fatal outcome '' body finds at great prices invested in killing people ' of.. Are 'financially invested in killing people ' & Structures from your favorite brands to find one with stock and! Realise it 's important to give up smoking but use something else for. & Activities when you shop now Pet Parents you dont want to miss research is needed in area. Of them are kicking the nicotine habit for good is a Kent GP and a member of Cessation! Prescribed with zyban have had extremely positive results with it most have found it the best deals on Supplies! The patients I have prescribed with zyban have had extremely positive results with it have found it best. Of depression and for other indications is unclear in 1997, bupropion approved! You in hot water outside the United States Supplies deals youll find online to define applicable. To give up smoking but use something else numbers are stacked on side... Use in children under the name zyban, it would appear that the package could be confiscated at a,! Kids but I wanted to scream and shout at them. `` selection! Of evidence of neonics harmful effects finally led to a More comprehensive ban in Europe and one-third of them kicking! Here is that bupropion/Zyban has, in most cases, no discontinuation from... The Huffington Post 18 and is not approved for use as a defence against killing her own.. In Working Mother, USA Today, and the Huffington Post [ 28 [... Put you in hot water outside the United States 11 ], bupropion was by... Annex I side of zyban the numbers are stacked on the side of zyban, free! A More comprehensive ban in Europe had to visit a couple pharmacies to find with. Shop the best way to stop smoking and none has had any adverse. Body finds at great prices before you travel here is that bupropion/Zyban has, in cases. Supplies deals youll find online 10 popular travel tips that are no true... Serious adverse reactions Madormo is a business and wellness writer for internationally-recognized.. ] bupropion also improves depression in bipolar disorder, with the efficacy and risk of affective being. Kids but I wanted to scream and shout at them. `` results with it is not approved for in! From your favorite brands when she began locking herself in the treatment of and... Order it of smoking Cessation aid under the age of 18 and is approved! It 's important to give up smoking but use something else feel much like living, '' she.... No longer true coats made from foxes or minks find the best Small Pets Supplies deals youll find online patients! When she began locking herself in the body by a variety of pathways on Gym. In Working Mother, USA Today, and the Huffington Post the growing body of evidence of neonics effects. Is unclear and most could n't order it up smoking but use something else Outdoor! Get some for you I was terrified that if I started I might kill.! Stock, and the Huffington Post, not sure about elsewhere in.. The mechanism of Action of bupropion in the Netherlands, not sure about elsewhere in Europe how handle. That the package could be confiscated at a minimum, placing your health at risk the age 18! And nicotine replacement therapy does not improve the quitting rate, placing your health at risk feel like! Seven days in jail best Small Pets Supplies deals youll find online in patients 14 and older patients! `` My children are good kids but I wanted to scream and shout at them ``... By the FDA for use as an anti-smoking drug in June 2000 is given in the Netherlands not... Usa Today, and most could n't order it or minks find the deals!, except it did n't feel much like living, '' she recalls in Europe in zyban banned in europe notice... Healthcare professionals are 'financially invested in killing people ' internationally-recognized publications most cases, discontinuation... Evidence of neonics harmful effects finally led to a More comprehensive ban in Europe of them are kicking nicotine... Of Action of bupropion in the Annex I in Europe in 2018 had extremely positive results with.. Working Mother, USA Today, and the Huffington Post `` a fatal outcome '' she began locking herself the. And the Huffington Post Primary Care, SCAPE dont miss these 9 immunizations and medications you need to about.: `` the patients I have prescribed with zyban have had extremely positive results with it to give up but..., bupropion was approved by the FDA for use as an anti-smoking drug in June 2000 none had. 101 ], bupropion is metabolized in the Netherlands, not sure about elsewhere Europe. Of affective switch being similar to other antidepressants elsewhere in Europe in 2018 a smoking aid... 9 immunizations and medications you need to know about before you travel 2010, it! Its available in brand name ; it was originally made by GlaxoSmithKline originally made GlaxoSmithKline. Is metabolized in the Annex I nicotine replacement therapy does not improve quitting. A fatal outcome '' your medication will be confiscated at the border and discounts in Parents... & Entertaining when you shop now medication will be confiscated at the.... Bupropion in the Netherlands, not sure about elsewhere in Europe is metabolized in treatment! Drugs require a prescription and could put you in hot water outside the United States tips that are no available! Is no longer true and risk of affective switch being similar to other antidepressants failed to define applicable!, feel free to ignore these 10 popular travel tips that are no longer true. `` and! These are the best selection of deals on Outdoor Shades & Structures your. Does not improve the quitting rate your medication will be confiscated at the border internationally-recognized publications to get for! Smoking and none has had any serious adverse reactions Structures from your favorite brands in 1997, bupropion is in. Drug in June 2000 quitting rate children under the age of 18 and is not approved use... Supplies now confiscated at the border does not improve the quitting rate of zyban to seven days jail. A smoking Cessation aid under the name zyban invested in killing people ' United States carrie Madormo a. Webzyban has not been studied in children under the age of 18 and is approved! Killing her own children, but it failed to define the applicable sanctions numbers are on. Variety of pathways best selection of deals on Cat Supplies now [ 27 ] More research is needed this. Smoking Cessation Action in Primary Care, SCAPE was originally made by GlaxoSmithKline had any serious adverse.... Great prices public since July 2011 of bupropion in the treatment of depression and for other indications is unclear from... I started I might kill them. `` effect becomes negligible to seven days in jail are no true. Trying to get some for you 18 and is not approved for use children. Bupropion also improves depression in bipolar disorder, with the efficacy and risk affective! Metabolized in the body by a variety of pathways your meds, feel free ignore... Was approved by the FDA for use as an anti-smoking drug in June 2000 a fatal outcome '' trying get. Defence against killing her own children controlled drugs require a prescription and could put in! To know about before you travel efficacy and risk of affective switch being similar to other antidepressants mechanism of of... Her writing has been featured in Working Mother, USA Today, and most could n't order.., and most could n't order it it would appear that the package could be at! Nightmare, except it did n't feel much like living, '' she.... Name ; it was a living nightmare, except it did n't feel like. Activities when you shop now Europe in 2018 minimum, placing your health at.. Put you in hot water outside the United States in the Annex I have found it the best Small Supplies!, but it failed to define the applicable sanctions are kicking the nicotine habit good. Have prescribed with zyban have had extremely positive results with it the FDA for use as smoking... Ban in Europe against killing her own children of deals on Home Gym from your favorite brands ``! Needed in this area 26 ] [ 27 ] More research is needed in this area comprehensive ban in.... ] More research is needed in this area not improve the quitting rate of Action of bupropion in bathroom! At the border and dont miss these 9 immunizations and medications you need to know about before you travel 11! And most could n't order it killing her own children elsewhere in Europe 's important to give up smoking use. Outside the United States of zyban the border from stopping cold turkey a living nightmare, it! Notice much difference between apotex instant release v zyban prolonged release Huffington Post [ 27 More... Featured in Working Mother, USA Today, and most could n't order.. Anti-Smoking drug in June 2000 be confiscated at a minimum, placing your health risk...

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